Romiplostim mitigates dose-limiting thrombocytopenia of erucic acid for adrenomyeloneuropathy
نویسندگان
چکیده
منابع مشابه
Romiplostim and eltrombopag for immune thrombocytopenia: methods for indirect comparison.
OBJECTIVES Immune thrombocytopenia (ITP) causes increased platelet destruction and suboptimal platelet production, increasing risk of bleeding. This analysis uses a Bayesian metaregression model to indirectly compare effectiveness of the thrombopoietin mimetics romiplostim and eltrombopag for increasing platelet counts, and contrasts the results with those of non-Bayesian approaches. METHODS ...
متن کاملRemissions after long-term use of romiplostim for immune thrombocytopenia.
Immune thrombocytopenia (ITP) is an acquired autoimmune condition whereby autoantibodies against platelets lead to increased platelet clearance, suppression of megakaryocytopoiesis, and subsequent thrombocytopenia. ITP is associated with increased bleeding risk, and the primary goal of therapy is to prevent clinically significant bleeding. Steroids, and in some cases intravenous immunoglobulin,...
متن کاملRomiplostim as a treatment for immune thrombocytopenia: a review
"Immune thrombocytopenia" (ITP) is an autoimmune disorder that leads to peripheral destruction, as well as a decreased production of platelets. ITP most commonly presents as mild mucocutaneous bleeding. Though it is rare, the leading cause of mortality in persons with ITP is intracranial hemorrhage and those that do not respond to therapy are at increased risk. Our understanding of the pathophy...
متن کاملTreatment of 5 dogs with immune-mediated thrombocytopenia using Romiplostim
BACKGROUND Immune thrombocytopenia (ITP) in dogs is analogous to that in humans. Romiplostim, a novel thrombopoietin receptor (TPO-R) agonist, is currently used for the treatment of refractory ITP in humans, but not in dogs. Here, we describe the response to romiplostim in five dogs with refractory ITP. Five dogs with severe and refractory ITP (three primary and two secondary) received romiplos...
متن کاملSelf-administration of romiplostim in patients with chronic immune thrombocytopenia
Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City; New York Presbyterian Hospital, Departments of Pediatrics and Medicine, Division of Hematology, New York; Cancer Care Centers of South Texas/ US Oncology, San Antonio, Texas; 4 Jane Ann Nohl, Division of Hematology, University of Southern California Keck School of Medicine, Los Angeles; University of P...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2015
ISSN: 0007-1048
DOI: 10.1111/bjh.13440